ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

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ey0018.5-15 | Advances in skeletal biology | ESPEYB18

5.15. PTHrP targets salt-inducible kinases, HDAC4 and HDAC5, to repress chondrocyte hypertrophy in the growth plate

Nishimori Shigeki , Wein Marc N , Kronenberg Henry M

Bone. 2021 Jan;142:115709 Abstract: https://pubmed.ncbi.nlm.nih.gov/33148508/In brief: In the developing bone, PTHrP signaling inhibits hypertrophic differentiation, the key step in the coupling of chondrogenesis and osteogenesis during endochondral bone formation. The current paper reviews findings of previous knockout-studies on PTHrP-induced signaling including HDAC4/5, salt-ind...
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Published by BioScientifica

ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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